A study shows that coffee is not only for a morning energy boost. But it has more benefits it may help protect against the development of dementia. Researchers at Indiana University discovered that caffeine and 23 other compounds kick-start an enzyme known as nicotinamide mono nucleotide adenylyl transferase 2, or NMNAT2, and it’s this compound that scientists say may block the effects of Nero degenerative disorders. The scientists screened over 1,280 compounds, including existing drugs, in order to identify 24 compounds that could potentially increase the enzyme’s production.
What the study show?
The study, led by Hui-Chen Lu of the Department of Psychological and Brain Sciences, followed research done by Lu’s team in 2016, which found that the NMNAT2 enzyme not only protects neurons in the brain from stress but binds to tau proteins via the “chaperon function.”
Misfolded proteins are implicated in such Nero degenerative disorders as Parkinson’s, Huntington’s and Alzheimer’s diseases, as well as amyotrophic lateral sclerosis, known as ALS or Lou Gehrig’s disease.
With no known cure and the number of people affected expected to triple by 2050, the Alzheimer’s Association estimates that by mid-century someone in the U. S will develop Alzheimer’s disease every 33 seconds
How to prevent Dementia, Alzheimer’s?
Dementia is a group of symptoms, not a disease in itself, associated with diminished cognitive skills such as memory, reasoning and communication, severe enough to interfere with daily activities.
Alzheimer’s is the most common type of dementia, which worsens over time, and accounts for as much as 80 percent of known dementia cases.
What causes Alzheimer?
Researchers are still unclear on the precise causes of Alzheimer’s; it is known that the condition arises as a result of brain cell death. The formation of ‘tangles,’ which are misfiled strands of a protein called tau, is believed to play a role in brain cell death.
They still not sure the causes Alzheimer’s, but the fact that it stems from brain cell death due to the “tangling” of tau proteins is an important clue in getting to the bottom of how to keep it from happening,
The Significance of NMNAT2 for ‘Blocking’ Dementia “Lu’s earlier research found that mice altered to produce misfiled tau also produced lower levels of NMNAT2.
How does the coffee helps?
The researchers administered caffeine to mice modified to produce lower levels of NMNAT2. As a result, the mice began to produce the same levels of the enzyme as normal mice.”
Caffeine was found to be one of the most effective at increasing NMNAT2 production.
Significantly, 13 other compounds were identified that actually lowered this important enzyme’s production. They’re important, Lu says, because they help researchers understand how they might contribute to dementia. According to Lu:
“This work could help advance efforts to develop drugs that increase levels of this enzyme in the brain, creating a chemical ‘blockade’ against the debilitating effects of Nero degenerative disorder.
How’s the coffee Might Benefit Your Health?
The coffee was one of the 24 substances that increased NMNAT2 formation to effectively inhibit Nero degenerative disorders such as dementia.
While Lu says knowing this information will help other scientists create drugs to increase levels of the NMNAT2 enzyme for the purposes of combating dementia, coffee has been identified as having other substances that are useful. Also, studies indicate that coffee offers benefits in cancer prevention and treatment.
One study showed that drinking four or more cups of caffeinated coffee daily lowered the risk of colon cancer recurrence or death by 52 percent.
A meta-analysis on coffee and cancer risk published in 2016 concluded with the statement:
“Our study demonstrates that coffee intake can reduce the risk of oral, pharynx cancer, colon cancer, liver cancer, prostate cancer, endometrial cancer and melanoma by 31 percent, 13 percent, 54 percent, 11 percent, 27 percent and 11 percent respectively for the highest versus lowest coffee intake. Furthermore, coffee intake could reduce the risk of liver cancer, prostate cancer and endometrial cancer by 27 percent, 3 percent and 12 percent with an increment of 2 cups of coffee intake.”
The World Health Organization reversed its longtime position that coffee may cause cancer and the World Health Organization’s International Agency for Research on Cancer (IARC) reported that coffee consumption may actually help reduce chronic disease. Another study reported that drinking at least five cups of coffee a day reduces the risk of some brain cancers by as much as 40 percent.
Careful now, What You Put in the Coffee may be Problems?
If you haven’t heard how damaging fake creamers and artificial sugars are — in some peoples’ minds, the only way to make it palatable — you may want to sit up and take notice. Another way of saying it is: You know what’s in your coffee, but do you know what’s in your creamer?
. High-fructose corn syrup, implicated in mitochondrial malfunction
. Di potassium phosphate, often used in fertilizer and cosmetics
. Partially hydrogenated soybean oil, which contains trans fats, known to cause inflammation
. Mono- and diglycerides may be synthetic, derived from partially hydrogenated oils or both
. Sodium casein ate, often treated with the chemical sodium hydroxide, which can damage or suppress nutrient absorption
Raw, organic cream from pastured cows is a far better creamer in your coffee because it’s natural and contains a healthy amount of “good” fat, but your best option is to drink your coffee black.
Coffee Sweeteners better without it:
Artificial sweeteners another popular item for coffee, It could be worse for you than sugar and fructose. Aspartame, for instance, is shown in many studies to increase weight gain, worsen insulin sensitivity and even cause cancer and neurological problems.
You can use natural sweeteners such as honey and agave syrup may seem to be much healthier than chemically contrived sweeteners, they contain high amounts of fructose and may be highly processed.
If you like your coffee sweetened, you can try the herb Stevie, which doesn’t raise your blood glucose level like sugar does. It may be one of the safest alternatives for sugar. Luo han guo, also known as monk fruit, is another natural sweetener with this attribute and some say it has a superior flavor.